Nrf2, but not β-catenin, mutation represents an early event in rat hepatocarcinogenesis
نویسندگان
چکیده
منابع مشابه
Transgenic disruption of gap junctional intercellular communication enhances early but not late stage hepatocarcinogenesis in the rat.
Much experimental evidence supports the conclusion that loss of gap junctional intercellular communication (GJIC) contributes to carcinogenesis. Transgenic rats featuring a dominant negative mutant of the connexin 32 gene under albumin promoter control (Cx32Delta Tg-High and Cx32Delta Tg-Low lines, respectively with high and low copy numbers of the transgene) have disrupted GJIC, as demonstrate...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2015
ISSN: 0270-9139
DOI: 10.1002/hep.27790